Sam Rosen

Biography

     I received my Bachelor's degree in Physics with a minor in Computer Science from Boston University in 2020, graduating Magna Cum Laude. I began my PhD in 2020 and I joined the Wilson Lab in 2021. 

Research

     Heterogeneity in pathway signal transduction among cell populations is widely observed. While numerous studies have focused on why pathway signal transduction heterogeneity arises in cell populations, little work has been done investigating the purpose signal transduction heterogeneity serves for cell population function. In order to study this, I am developing an all optical feedback control system that combines both optogenetics and feedback control theory to reduce cell to cell variations in signal transduction. I plan on using my developed system to reduce signal transduction heterogeneity in an essential stem cell differentiation pathway and discover the relationship between signal transduction heterogeneity and stem cell fate decisions. 

     In addition to this project, I am also working on developing a GNN for drug discovery and applying my feedback system to control the stress response among Chinese Ovarian Hamster (CHO) cells for antibody production.